My cat tested positive for the toxin that is produced by clostridium perfringens. He has had diarrhea now for what seems like forever. He recently was treated with clindamycin for a staph infection in his urinary tract. While on this medicine it cleared up his diarrhea.. For about two months, then it started again. This is when I got a diarrhea panel done and it tested positive for the toxins.

We first tried metronidazole.. No success.

Right now he is on tylan powder and it’s been about a week. He is no longer going on the floor like usual, but I did notice little puddles of diarrhea In the litter boxes. I don’t believe it is any of my other cats because they never have had issues with diarrhea. Well tonight he threw up multiple times. It was mostly his cat food. And colored like his food. I waited about an hour and fed him a little more food which he kept down.
I did not give him his medicine tonight. I am going to call my vet in the morning.

The next step would be for him to go on clindamycin again. This was my vets last choice and she said she really didn’t want him to go on it again. Because it is not the safest medication for cats.
After this clears up he will be going on probiotics and a fiber supplement such as Metamucil.

I’m just really nervous about him being on clindamycin again. Have you seen this problem happen in cats before? Why is he not responding to any medication? Are there any other options? Ugh.

Thank you.